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long term exposure to second hand smoke or irritants, such as air pollution, dust or workplace fumes and biomass exposure, such as wood smoke can also contribute to COPD

However, MIF is a negative regulator of p53 expression and can protect the CSE-induced apoptosis of pulmonary vascular endothelial cells by combating p53-mediated caspase-dependent apoptosis pathways [121]

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To help adult users to completely switch to alternative nicotine products, it is important the other alternatives provide effective nicotine delivery comparable or close to that of conventional/combustibles cigarettes 22,23