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Stringer, M.L

They assume that if they aren't clearly happier after a few doses, the medication has failed

508,509 Lumasiran, a siRNA drug that targets hydroxy acid oxidase 1 to reduce hepatic oxalate production, was the first drug approved for PH1

For children on valproate for epilepsy, which can lead to a deficiency of carnitine (see Interactions section), the doctor will likely prescribe a dose of 100 mg/kg of body weight per day, not to exceed 2,000 mg per day