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A case-only analysis of three North American RA cohorts RA patients from the North American Rheumatoid Arthritis Consortium (NARAC) family collection, from the National Inception Cohort of Rheumatoid Arthritis Patients, and from the Study of New Onset Rheumatoid Arthritis (SONORA) has shown an association between smoking and anti-CCP in the NARAC and the National Inception Cohort, but not in the SONORA [71]

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In real terms, this led to price increases of up to 60 per cent