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This suggests a high level of TSNAs formation in the DH and MS products

We also downloaded level 3 DNA methylation data (i.e., JHC_USC HumanMethylation450K) 60, 61 and level 3 RNA expression data (i.e., UNC IlluminaHiSeq_RNASeqV2) 60, 61 on lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) from the large-scale database of TCGA 62 to provide validation for the identified smoking-related oncogenes

Similarly, when conditioning on our top variant, the Saunders et al