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And, because the federal minimum smoking age was raised to 21 in 2019, it is illegal to sell tobacco or marijuana to anyone under the age of 21 in Arizona

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This effect is best understood in the context of gene promoters where DNA methylation can impair physical binding of transcription enhancers and promote the recruitment of methyl-CpG-binding domain proteins that increase chromatin condensation and thus decrease the DNA accessibility for the transcriptional machinery (Portela and Esteller, 2010)

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Coupled with the potential gum disease that smoking can cause, decay can lead to tooth loss and a series of other dental issues like malocclusion (improper bite alignment).