tobacco in virginia colony The Golden Weed - Tobacco Cultivation in Colonial Virginia

And we do that all the time

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An analysis of the residual amounts of 69 harmful substances revealed that natural nicotine liquid contained 12,509 mg per liter (L) across 45 items, whereas synthetic nicotine liquid contained 23,902 mg/L across 41 items

As discussed earlier, dipping tobacco products contain tobacco-specific nitrosamines or TSNAs