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As a physician, I would suggest that the medicalization of smoking cessation therapy is one reason why so many people continue to smoke

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Additionally, e-cigarettes may provide a way for smokers to wean themselves off of nicotine, as users can gradually decrease the nicotine strength of their e-cigarettes over time

KEAP1 also serves as a sensor for endogenous and exogenous electrophiles and oxidants, as it contains several highly reactive cysteine residues that prevent its ability to target NRF2 for degradation

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