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The decline of the 21st century Although there were already unconvincing attempts as early as 1964 when the United States approved the Tobacco Advertising Code, which prohibited athletes from participating directly in advertisements and was ineffective, the actual decline of the relationship between tobacco and sport occurred in the first decade of the 2000s

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Indeed, two separate cohorts of young users of ENDS described reduced endothelium-dependent vasodilation and decreased nitric oxide bioavailability when compared to non-users [127, 128]