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The modifications included using a hybrid RdRP [from turnip vein-clearing virus (TVCV)] and Arabidopsis actin 2 (ACT2) as a promoter together with removal of cryptic thymine-rich intron sites plus selective introduction of introns (Marillonnet et al., 2004, 2005)

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J Environ Sci (China) 141:249260

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These patients, who have very low PD-L1 expression on their tumors, experienced a nearly five-fold improvement in three-year overall survival with receipt of a COVID vaccine