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Some studies have noted that although NK cells can clear certain damaged chondrocytes or pathogens in early OA, they also release ROS under highly inflammatory conditions, aggravating oxidative stress and indirectly activating ferroptosis pathways (116)

These findings highlight the efficacy of SFN treatment in attenuating keratinocyte hyperproliferation and cutaneous inflammation in psoriatic mice by regulating the expression of crucial inflammatory markers and chemokines, indicating its potential therapeutic value in managing psoriasis

Generally very safe with few side effects even at higher doses