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Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation

The original FDA nod was based on an overall response rate (ORR) of 57% and median duration of response (DoR) that had not yet been reached in 114 patients in the Phase I/II ARROW study

Thus, dietary supplement B 12 supplementation at 500 to 1000 g per day allows pernicious anemia and certain other defects in B 12 absorption to be treated with daily oral megadoses of B 12 without any correction of the underlying absorption defects

Competing interests The authors declare that they have no competing interests

For chronic conditions, full assessment should occur after a complete 812 week cycle