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Here we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J m 2 ) to tendon on opposite surfaces of the hydrogel, as we show with porcine and human tendon preparations during cyclic-friction loadings

The chemical also occurs naturally in some organs and soft tissues

Best Practices: Adhere to researched doses and routes, and monitor closelyhuman synergy data remain limited

But it also has a thousand other effects, tissue growth, insulin resistance, raising IGF-1 and the risk of acromegaly

By day 3-4 of multi-dose use, microbial contamination becomes likely