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As P-gp substrates, these compounds can undergo active efflux from intestinal cells back into the gut lumen, reducing their absorption and systemic bioavailability following oral administration [22]

In 1999 he was recruited to Harvard Medical School where his laboratorys research has focused primarily on understanding the role of sirtuins in disease and aging, with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer