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The nicotine inside can be extracted from tobacco or synthesized in a lab, but there is no actual tobacco leaf material
Another study tested the aerosol exhaled from e-cigarettes and found low levels of formaldehyde, acetaldehyde, isoprene, acetic acid, 2-butanodione, acetone, propanol, propylene glycol and nicotine, although the toxins from the aerosol were at a lower level than from conventional cigarettes
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When low-quality metal is heated hundreds of times, trace metals leach into the vapor you're inhaling