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142 This ANPRM aligns with policy as described in the article entitled A Nicotine-Focused Framework for Public Health. 128 written by a former FDA Commissioner and the Director for the FDA Center for Tobacco Products, which states that, The public health benefits of implementing a nicotine reduction policy for combustible cigarettes could be enormous because nicotine is responsible for getting smokers addicted to cigarette smoking and keeping them addicted long-term. It also concludes that the availability of potentially less harmful tobacco products could reduce risk while delivering satisfying levels of nicotine for adults who still need or want it. While the availability of these harm reduction products (e.g., electronic cigarettes) has been controversial because of their uptake among youth, they may have a significant role in reducing cigarette smoking among smokers and warrant further consideration for their role in improving public health

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[M]any cigarette smokers who have begun using filters, which keep out a small part of these harmful ingredients, find themselves smoking more and enjoying it less in order to consume the amount of nicotine their habits require. For McMorris, who had defended a number of drug users in court, nicotine was more akin to opiates than to any other drug