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Subcutaneous injection of high doses of nicotine in mice achieving plasma concentrations similar to those of heavy smokers also increased epidermal thickness although lower nicotine doses simulating the plasma levels of lighter smokers had the opposite effect 29

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"Tar," Nicotine, and Carbon Monoxide of the Smoke of 1294 Varieties of Domestic Cigarettes For the Year 1998: A Federal Trade Commission Report to Congress

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