Among the most differentially up-accumulated (Table 2) metabolites were Lipids (8 metabolites), Nucleotides/derivatives (4 metabolites), Terpenoids (2 metabolites), and Flavonoids (1 metabolite)
30 Associations between pack-years and cortical thinning were greatest in statistical significance in the medial and lateral prefrontal areas, posterior cingulate gyrus, precuneus, medial and lateral temporal areas, and the angular gyrus, regions that are all part of the default mode network
JJ: Investigation, Writing original draft
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