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Therefore, periostin is a marker of asthma disease progression 100-102

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Mass legal action instituted in the 1990s led to the Master Settlement Agreement in 1998 with US courts condemning major US cigarette companies to pay huge sums of money to the US government over a period of 25 years to compensate for some of the damage and expenses incurred in caring for the millions of people suffering ill health directly caused by smoking over the years

Not a significant difference in size, but enough to make it stand out a bit more