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For men with confirmed pituitary damage or disease, these peptides may not produce a meaningful response because the pituitary cant respond to the signal direct HGH replacement would be more appropriate

doi: 10.1016/j.jhep.2023.03.017

The enzyme aromatase is widely expressed in the forebrain of primates (including humans), and although estrogens are more associated with female functions, the expression of this enzyme in the CNS does not depend on plasma E2 levels (135, 136)

This combination is being studied in relation to recovery, body composition and cellular renewal via GH-related pathways