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Pharma companies are downsizing and some of them have closed their neuropsychiatric divisions because right now it is difficult to do that type of research and it is not economically profitable for pharmaceutical companies. Simon Chapman, professor of public health at the University of Sydney, takes a dim view of the medicalization of quitting

And because e-cigarettes are relatively new to the scene, until recently it hasnt been possible for researchers to conduct long-term studies tracking how vaping impacts health

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This is in fact conservative for our purpose