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In addition to its role in regulating seasonal physiology and influencing the circadian system and sleep patterns, melatonin is involved in cell protection, neuroprotection, and the reproductive system, among other possible functions

They are not approved for human or animal consumption, clinical administration, or therapeutic use by regulatory authorities such as the FDA

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To further investigate the impact of metformin treatment on mitochondrial metabolism in HCT116 and SW837 cells, mitochondrial dysfunction was assessed using three surrogate markers of mitochondrial function