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Cigarette smoke inhibits ciliary activity of the bronchial epithelium and phagocytic activity of macrophages in the alveoli, resulting in decreased clearance of foreign material and bacteria from the lung, which leads to increased infection and tissue destruction

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Particulates do make up part of tobacco smoke (thats why we can see the smoke in the air), but to really deal with the problems of tobacco smoke, you need to address both the particulates and the gaseous toxins