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The primary cartridge ingredient is propylene glycol, and the secondary ingredients are water, nicotine, and a flavor to replicate the taste of traditional smoking

Chang AK, Barrett-Connor E, Edelstein S: Low plasma cholesterol predicts an increased risk of lung cancer in elderly women

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However, the science here is less clear and potentially complex, as nicotine can also have vasoconstrictive effects (narrowing blood vessels) which might counteract any perceived benefit for some individuals