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In a randomized crossover trial, Esquivias-Motta et al.45 demonstrated a greater decrease in IL-6 levels with HFR versus OL-HDF

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Hormonal Imbalances Over-replacement may lead to IGF-1 levels above the normal range, which has been associated with: Increased risk of soft tissue overgrowth Possible long-term concerns with cancer risk, though data in physiologic replacement doses remain limited GH therapy may also interact with thyroid, cortisol, or sex hormone levels, necessitating endocrine review

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