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In agreement with this view, our study showed that nicotine-promoted ROS production and this oxidative stress may likely be an upstream mechanism for the activation of NLRP3 inflammasome activation, which can be neutralized by N-acetyl-cysteine (NAC), a ROS inhibitor

The EAPC values for ASRs of YLLs and DALYs were similar to those of deaths, with the highest negative EAPC values found in the high-SDI region, at -3.22 (95% UI: -3.35 -3.09) and -2.91 (95% UI: -3.02 -2.80), respectively

DOI: 10.1002/14651858.CD008581.pub2 Stokes PRA, Jokinen T, Amawi S, et al