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Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatographymass spectrometry

101 Whereas, the classical explanation is that, while hydroxychloroquine impaired phago/lysosomal function, it also appears to work in a lysosome-independent manner by impacting on intracellular TLRs, particularly TLR9, by inhibiting the production of TNF, and by interfering with the processing of the conversion of the membrane-bound pro-TNF into soluble mature protein

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Estos procesos causan una alteracin de la formacin de ATP en la va de glucosa a piruvato, con ello se logra la acumulacin de subproductos metablicos (sobre todo lactato) que estn muy asociados al entrenamiento con RFS

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