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In May 2016, the government announced various changes to the tobacco laws, in efforts to achieve a smoke-free society

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Second, we did not apply additional pleiotropy-robust methods such as MR-PRESSO, which could help identify and correct for potential outlier variants, and thus we cannot completely rule out the presence of residual horizontal pleiotropy

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smokeless tobacco market continues to exhibit growth despite regulatory scrutiny as well as increasing public awareness of its health risks, 7.5% of U.S