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They increase epithelial permeability caused by tight junction damage, stripping the mucociliary epithelial barrier and leading to a compromised defense mechanism against pathogens, peribronchial inflammation, oxidative stress, and ultimately, a more detrimental immune response (Figure 1)

Especially since that risk could be curbed with other anti-drunk driving measures and by universalizing anti-smoking laws at bars, restaurants, and other hospitality establishments