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First, if we assume that e-cigarettes are used as a smoking cessation aid, we hypothesize that smokers with respiratory symptoms at baseline are more likely to initiate e-cigarette use than smokers with fewer symptoms (hypothesis 1)

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Farmers found it expedient to create markets for their tobacco near to the site of production, and soon the tobacco marketing industry had organized itself in the form of the Eastern Belt, though that term itself was not yet in use

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