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When IGF-1 is expressed in a muscle-restricted, locally acting form, it can sustain myocyte hypertrophy and preserve age-independent regenerative capacity without the systemic pathology associated with whole-body IGF-1 elevation

The primary antibodies that were used were as follows: antibodies against cardiac troponin T (#ab209813, 1: 3000 for cardiomyocytes), antibodies against Col11 (#ab270993, 1:2000), antibodies against Vimentin (#ab24525, 1:300) and cardiac troponin T (#ab8295, 1: 2000 for myocardial tissue) were obtained from Abcam (Cambridge, UK)

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Most data are preclinical, and converting them into consistent therapy outcomes is difficult

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