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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

The REDEFINE1 Phase 3 trial showed 22.7% weight loss over 68 weeks in adults with obesity/overweight (no T2DM), exceeding the 20.2% seen with tirzepatide in SURMOUNT5

Risks include nausea, cardiovascular effects, priapism (prolonged erection requiring emergency care), skin changes, and unknown long-term effects

Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle

Animal studies The animal study was approved by the Institutional Animal Care and Use Committee (IACUC) at Yonsei University (Seoul, Korea) under IACUC Approval No