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A Cochrane systematic review, the gold standard of evidence-based medicine, explicitly concluded that it was "not able to provide reliable evidence that nicotine is a useful treatment for Alzheimer's disease [12] ." The few small studies showing modest short-term effects on some cognitive tests have not been reproduced at scale

YOUTH American Indian and Alaska Native high schoolers have the highest current cigarette smoking rate of any other race or ethnicity at 16.2%, compared to 5.8% overall

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