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Synaptic density: Microscopy studies confirm increased dendritic spine density in Dihexa-treated animals, providing structural evidence for the observed cognitive improvements

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Researchers note that the 12mg cohort had not reached a weight loss plateau at 48 weeks, suggesting efficacy may continue to increase with longer exposure

98 As with leptin, PYY 3-36 has been seen to cross the blood-brain barrier and act on the Y 2 receptor, a presynaptic inhibitory autoreceptor on NPY neurons