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[6] In extreme forms, this may manifest as leukoplakia or stomatitis nicotina (smoker's keratosis)

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The affected group not only exhibited a higher prevalence of residing in smoking households, but urothelial carcinoma was diagnosed in 35.5% of dogs with measurable urinary cotinine levels, compared to only 15.5% in those with undetectable cotinine concentrations (p=0.016) 3

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