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"Addiction is primarily defined as a loss of control on the use of a substance and continued use despite the consequences," Bernard Le Foll, Chair of Addiction Psychiatry within the Department of Psychiatry at the University of Toronto, told Live Science in an email

Long term use may be associated with several adverse effects including Clostridium difficile intestinal infection, low magnesium levels, pneumonia, fractures, cardiac events, iron deficiency, and rebound reflux symptoms

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