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Circulation 105(3):373379 Aiello LP, Wong J-S (2000) Role of vascular endothelial growth factor in diabetic vascular complications

PRO-DEATH FUNCTIONS OF GSH METABOLISM Although GSH is classically viewed as a cytoprotective antioxidant, growing evidence indicates that under specific metabolic and microenvironmental conditions, it can also facilitate regulated cell death

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It should be noted that inhibition of this enzyme reduces vascular oxidative stress and also circulating levels of uric acid