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21 A subsequent 2018 Cochrane SR of antidepressants in people with co-occurring depression and alcohol dependence found only low-quality evidence supporting clinical use of antidepressants, when all antidepressants including tricyclic antidepressants were considered

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National surveys of cannabis use would suggest that, overall, an estimated 8 % of European adults (22.8 million aged 15 to 64) have used cannabis in the last year

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