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Volatile organic compounds (formaldehyde, acrolein) and carbonyls can damage airways and DNA

COPD (Chronic Obstructive Pulmonary Disease): A progressive disease that makes it hard to breathe, often manifested as chronic bronchitis or emphysema

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Initially, the government focused efforts to deter smoking on public awareness campaigns and warning labels on the product

The detection of SBS4 (a hallmark of tobacco-induced mutagenesis) in the organoid model indicates that chronic WCSE exposure can elicit molecular alterations resembling those found in smoker-derived tumors, effectively bridging in vitro oxidative adaptation with in vivo mutational landscapes