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Most industry advertising resources were reallocated to other categories, including price discounts paid to cigarette retailers or wholesalers, with a combined total of $7.7 billion, accounted for 92% of all 2018 expenditures

Additionally, when comparing the effects of adding different flavors, the addition of mint flavor (M0 vs Air) resulted in the highest number of differentially expressed genes (Fig

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The global market size of these products is expected to grow to nearly $33 billion U.S