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The finding suggested that this class of compounds is responsible for most of the frameshift mutagenic activity of cigarette smoke condensate detected in TA98

On 30 October 2019, the State Tobacco Monopoly Administration and the State Administration for Market Regulation jointly issued the first public notice on protecting minors from e-cigarettes, explicitly prohibiting tobacco advertisements targeting minors and strengthening content review in film and television 18

Clofazimine is at least partially metabolised in the liver via CYP3A4 and CYP1A2, thereby TB smokers may experience increased metabolite synthesis, potentially necessitating dosage adjustments

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After 2 weeks of usual treatment with a 21-mg patch, participants who fail to quit smoking (target n = 400) will be randomized to receive escalating doses of a nicotine patch vs matching placebo patches for an additional 10 weeks or up to a maximum dose of 84 mg per day