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It took nearly a century of scientific study, from the mid-1800s to the landmark US Surgeon Generals report in 1964, before smoking was officially recognized as a cause of lung cancer

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Rates exclude deaths in Puerto Rico and other US territories

Mental Health Disorders : Psychological conditions like anxiety, depression, and PTSD significantly increase addiction risk as individuals use substances as a form of self-medication to cope with distressing symptoms

2023 National Survey on Drug Use and Health: Detailed tables