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Glioma cells with FAO inhibited by etomoxir, a CPT1 inhibitor, exhibits a profound decrease in NADPH levels, reduced GSH content and elevation of intracellular ROS levels

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We verified the impact of ACTL6A on GSH synthesis and confirmed that ACTL6A KD led to reduced expression of certain genes (GCLC, GPX2, GPX4, SLC7A11, SLC1A5, GSS, GLS, etc.) involved in the GSH synthesis pathway (Supplementary Fig

J Am Coll Nutr 1994;13:559-64