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Discussion Understanding how nicotine affects decision-making has been challenging, because two different physiological aspects need to be distinguished 41 : (i) nicotine as a reinforcer that directly activates the dopaminergic system to produce reinforcement and nicotine-seeking, and (ii) nicotine as a neuromodulator that alters nicotine-independent decision-making processes by modifying the dynamics and computational properties of cholinoceptive circuits

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