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Excessive iron levels can generate produce ROS via the Fenton reaction, activating various intracellular signaling pathways that enhance bone absorption and inhibit bone formation, thereby contributing to osteoporosis

Glutamine-derived -KG can enter the TCA cycle to produce energy for the cell or proceed backwards via the reductive carboxylation to provide an alternative source of lipid synthesis

Structural basis for the inhibition of the eukaryotic ribosome

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Mechanistically, glutathione is understood to inhibit the enzyme tyrosinase and shift melanin production from darker eumelanin toward lighter pheomelanin, which can make skin look brighter and more even over time