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Gale N, McEwan M, Camacho OM et al (2021) Changes in biomarkers after 180 days of tobacco heating product use: a randomised trial

It is commonly used for its relaxing and euphoric effects, but it can also cause adverse effects like anxiety, paranoia, and memory impairment

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Nicotine is a marker for other toxic components of thirdhand smoke, but is also a concern in itself as nicotine can be changed into the highly toxic and carcinogenic tobacco-specific nitrosamine NNK, as shown by researchers at Lawrence Berkeley National Laboratory