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These include: Kinds of toothpaste and mouthwashes that contain sodium lauryl sulphate Lesser mouth injury from the dental operation, sports injuries, hard brushing of teeth, or accidental bite Food irritations to acidic foods like lemon, strawberries, and pineapples, and other trigger foods like coffee, chocolate, eggs, cheese, nuts, and spicy foods Allergic reaction to bacteria in your mouth Deficiency of essential vitamins, particularly B-12, folate, zinc, and iron Dental braces Emotional stress, anxiety, and deprivation of sleep Hormonal shifts during menstruation Nonsteroidal anti-inflammatory medications like ibuprofen Bacterial, fungal, or viral infections Sometimes, mouth ulcers also can be a sign of more severe conditions that demand medical treatment, such as: Celiac disease (a condition in which your body is unable to tolerate gluten) Diabetes mellitus Inflammatory bowel disorder, such as ulcerative colitis and Crohns disease A weak and damaged immune system that makes your body to attack the healthy mouth cells instead of pathogens such as bacteria and viruses Behcets disease (a condition that creates inflammation throughout your body) HIV/AIDs Cancer of the mouth can initially look like a mouth ulcer