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Persistent oxidative stress induces mitochondrial fragmentation and genomic adaptation, while activation of the AKTGSK3NRF2 axis stabilizes antioxidant defenses

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For metabolomics datasets, where sample sizes were limited ( n = 3 or n = 8 per group) and data did not meet parametric assumptions, nonparametric KruskalWallis tests were applied, followed by appropriate post hoc comparisons

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