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Roll-ups and natural tobacco are less harmful: Its a common belief that rolling tobacco contains less of the harmful chemicals and components than machine made cigarettes
Although mechanisms remain uncertain, smoking-related inflammation, oxidative stress, and DNA damage are thought to worsen outcomes [152]
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Psychopharmacology 233:32493257 Brody AL, Mandelkern MA, Jarvik ME, Lee GS, Smith EC, Huang JC, Bota RG, Bartzokis G, London ED (2004a) Differences between smokers and nonsmokers in regional gray matter volumes and densities