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Some studies have shown that metformin can reduce the absorption of vitamin B12 in 30% of people with type 2 diabetes (Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy)

Office of Dietary Supplements Vitamin B12. NIH Office of Dietary Supplements, U.S

Heavier individuals may need higher absolute doses to achieve equivalent tissue concentrations, while lighter individuals may find lower doses sufficient

Can BPC 157 and TB 500 be studied together

We reviewed Sikiric 1993-2026 (Zagreb, over 150 BPC-157 papers), the AJSM 2026 systematic review (35 preclinical studies), the 2026 pilot PK study in two healthy subjects, and the February 2026 STAT review