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(In 2008, Canada's two largest tobacco companies paid more than $1 billion in fines and pleaded guilty to helping supply the contraband market)

Most manufacturers offer nicotine levels ranging from 0mg to 50mg per millilitre, allowing users to gradually reduce their consumption over time, but the maximum strength legally available in the UK is 20mg per millilitre (a 2% strength e-liquid)

The chart below depicts use of these products

Eventually, this can lead to habit, reduced expression of receptors, higher use, and eventually, dependence

"Altria still keeps the legacy of the Western heritage of Marlboro, often with images of cowboys," Jackler said